Effects of Sensitization to Dinitrochlorobenzene (DNCB) on Clinical Pathology Parameters and Mitogen-Mediated Blastogenesis in Cynomolgus Monkeys (Macaca, fascicularis)
نویسندگان
چکیده
منابع مشابه
Reference values of clinical pathology parameters in cynomolgus monkeys (Macaca fascicularis) used in preclinical studies
Nonhuman primates are increasingly used in biomedical research since they are highly homologous to humans compared to other rodent animals. However, there is limited reliable reference data of the clinical pathology parameters in cynomolgus monkeys, and in particular, only some coagulation and urinalysis parameters have been reported. Here, we reported the reference data of clinical chemical, h...
متن کاملEstimation of Glomerular Filtration Rate in Cynomolgus Monkeys (Macaca fascicularis)
To estimate the glomerular filtration rate (GFR) in cynomolgus monkeys (Macaca fascicularis), a three-blood-sample method using iodixanol was assessed in comparison with the conventional multisample strategy using inulin. Iodixanol and inulin were coadministered intravenously 40 mg I/kg and 50 mg/kg, respectively, to male monkeys, followed by blood collection 60, 90 and 120 min later. A close c...
متن کاملTechnique for orthotopic liver transplantation in cynomolgus monkeys (Macaca fascicularis)
Purpose Recent studies investigating new strategies to modulate the immune system have utilized animal models of liver transplantation (LT). However, the anhepatic phase (AHP) remains a crucial problem in LT. The aim of the present study is to introduce a technique for successful orthotopic LT in cynomolgus monkeys using an early-reperfusion strategy. Methods Orthotopicallo-LT was performed w...
متن کاملEpidemic typhus infection in cynomolgus monkeys (Macaca fascicularis).
A nonhuman primate model of clinical Rickettsia prowazekii infections was developed in cynomolgus monkeys (Macaca fascicularis). Monkeys infected intravenously with 10(7) plaque-forming units developed clinical signs of illness and pathological changes characteristic of epidemic typhus infection in humans. Increases in total leukocyte counts, serum alkaline phosphatase, blood urea nitrogen, and...
متن کاملTracking cells implanted into cynomolgus monkeys (Macaca fascicularis) using MRI
Regenerative therapy with stem cell transplantation is used to treat various diseases such as coronary syndrome and Buerger's disease. For instance, stem-cell transplantation into the infarcted myocardium is an innovative and promising strategy for treating heart failure due to ischemic heart disease. Basic studies using small animals have shown that transplanted cells improve blood flow in the...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 1990
ISSN: 0192-6233,1533-1601
DOI: 10.1177/01926233900184p202